Amounts to be administered and administration route:
Caninsulin should be administered once or twice daily, as appropriate, by subcutaneous injection. Alternate the injection site daily. Before first use shake the vial thoroughly until a homogeneous, uniformly milky suspension is obtained. Foam on the surface of the suspension formed during shaking should be allowed to disperse before the product is used and, before each subsequent use, the product should be gently mixed to maintain a homogeneous, uniformly milky suspension before use. Agglomerates can form in insulin suspensions: do not use the product if visible agglomerates persist after shaking thoroughly.
Vial: Before each use invert the vial a few times before use until a homogenous suspension is obtained. A 40 IU/ml insulin syringe should be used.
Cartridge: Before each use invert the vial a few times before use until a homogenous suspension is obtained. The cartridge is designed to be used with VetPen. VetPen is accompanied by a package leaflet with detailed instruction for use to be followed. The injection procedure when using VetPen is as follows:
1Peel the protective film from a new pen needle. Screw the pen needle straight onto the cartridge holder. Remove the outer protective needle cap from the pen needle. Replace the pen cap onto the insulin pen. Turn the pen up and down at least 10 times.
2It is important to remove the air from the cartridge (prime the pen) before use to avoid injection of air and ensure proper dosing. Dial 1 unit on the dose selector. Remove the pen cap and the needle cap. Position the pen carefully with the needle pointing vertically upwards. Tap the cartridge gently with your finger a few times to push any air bubbles to the top of the cartridge. Push and hold the release button towards the needle until the arrow (>) on the pen body points to the start line (-) on the dose selector. A small amount of insulin may appear at the needle tip before the pen is fully primed. Repeat steps 1 and 2 until insulin drips actively or squirts out of the needle tip. Confirm that the pen is fully primed by ensuring that the air bubble is no longer visible in the cartridge window during inversion. The insulin pen is now primed and ready for use.
3Make sure the arrow (>) on the pen body points to the start line (-) on the dose selector. If it does not, please refer to ‘Priming Advice’ on the leaflet supplied with the VetPen.
4Dial up the number of units required per your veterinary surgeon’s direction. Never attempt to forcefully dial back the dose selector, as doing so may damage the insulin pen and result in inaccurate dosing. If at any time you select too high a dose, we recommend that the incorrect dose is fully expelled into a safe place and the required dose is redialled. Make sure before injecting that the arrow (>) points towards the correct number of units on the dose selector.
5The injection should be performed subcutaneously, 2 to 5 cm (¾ to 2 in) from the dorsal midline, varying from behind the scapulae (shoulder) to the mid-lumbar region (mid-back) and alternating sides. Insert the needle using the injection technique recommended by your veterinary surgeon then push the release button towards the pen needle and hold it in place until the start line on the dose selector returns to the arrow on the pen body (>-). Releasing the button prematurely will result in incomplete delivery of the dose. After the start line returns to the arrow, wait for a minimum of 5 seconds before removing the needle from the skin.
If the needle is removed or dislodged from the skin too early, you may observe small drops of insulin leaking from the needle, which can result in incomplete dosing. If this occurs, do not attempt to re-dose. Wait and give your pet its usual dose at the next injection.
If the dose selector stops before the start line on the dose selector (-) returns to the arrow on the pen body (>), this indicates that your pet has not received a full dose. If only a partial dose is administered, do not attempt to re-dose. Wait and give your pet its usual dose at the next injection.
When changing between dosing devices (syringes or VetPen), owners should be advised to monitor their animal closely to detect any changes in behavior or clinical condition. A dose adjustment may be required.
A once daily injection is sufficient to reduce the blood glucose concentration in most diabetic dogs. However, the duration of action may vary, making it necessary to administer the insulin dose twice daily to some diabetic dogs.
In diabetic cats, it is necessary to administer Caninsulin twice daily.
The dose depends on the degree of deficit in the animal’s own insulin production and is therefore different in each case.
Dog: Insulin therapy is initiated with the starting dose of 0.5 to 1.0 IU/kg body weight once daily, rounded down to the lowest entire number of units.
Subsequent adjustment to establish the maintenance dose should be made by increasing or decreasing the daily dose by approximately 10% according to the evolution of the diabetes clinical signs and to the results of serial blood glucose measurement. Alterations in dose should not normally be made more frequently than every 3 days.
The duration of insulin action as determined by blood glucose curve, may require treatment to be administered twice daily. In such cases, the dose per injection must be decreased by 25% so that the total daily dose is less than doubled. For example for a 10 kg dog receiving 5 IU once daily, the new dose (rounded down to the nearest whole unit) would be 3 IU per injection initially. The new doses should be administered at 12-hour intervals. Further dose adjustments should be made progressively as previously explained. Following switching to twice daily dosing, it is recommended that the clinical signs and blood glucose response be monitored closely.
To achieve a balance between the generation of glucose and the effect of the product, feeding should be synchronized with the treatment and the daily ration divided into two meals. The composition and quantity of the daily food intake should be constant. In dogs treated once daily, the second meal is usually fed at the time of peak insulin effect. In dogs treated twice daily, feeding coincides with Caninsulin administration. Each meal should be fed at the same time each day.
Cat: The initial dose is 1 IU or 2 IU per injection based on the baseline blood glucose concentration, as presented in the following table. Cats require twice daily administration.
Cat blood glucose concentration
<20 mmol/l or < 3.6 g/l (<360 mg/dl)
≥20 mmol/l or ≥ 3.6 g/l (≥360 mg/dl)
The starting dose should not exceed 2 IU per injection.
The composition and quantity of the daily food intake should be constant.
Subsequent adjustment to establish the maintenance dose should be made by increasing or decreasing the daily dose according to the results of serial blood glucose measurement. Alterations in dose should not normally be made more frequently than every week. Increments of 1 IU per injection are recommended. Due to the day-to-day variation in the blood glucose response, and the variations in insulin responsiveness that are seen with time, larger or more frequent increases in dose are not recommended.
Maintenance phase in dogs and cats
Once the maintenance dose has been reached and the animal is stabilized, a long term management program needs to be established. The aim should be to manage the animal in such a way as to minimize the variations in its insulin requirement. This includes clinical monitoring to detect under or over dosage of insulin and adjustment of dose if required. Careful stabilization and monitoring will help to limit the chronic problems associated with diabetes, including cataracts (dogs), fatty liver (dogs and cats), etc.
Follow up examinations should be performed every 2-4 months (or more often if there are problems) to monitor the animal’s health, the owners records and biochemical parameters (like blood glucose and/or fructosamine concentration). Adjustments to the insulin dose should be made based on interpretation of the clinical signs supported by the laboratory results.
Somogyi overswing, also called rebound hyperglycaemia, is a response to an overdose of insulin insufficient to cause, potentially fatal, hypoglycaemia. As hypoglycaemia begins to develop, a hormonal response is triggered which results in the release of glucose from hepatic glycogen stores. This results in rebound hyperglycaemia which may also manifest as glycosuria for part of the 24-hour cycle. There is a danger that the Somogyi overswing is interpreted as a requirement for increase in the insulin dose rather than a decrease. This can be avoided by basing decisions on serial blood glucose measurements rather than single point measurements.
The ability of pet owners to recognize the signs of hypo- or hyperglycaemia and respond appropriately is very important.